The vehicle is invariably a van or truck-based emergency vehicle featuring red and white lights and sirens and a matching paint scheme (with the exception of GTA 1's Ambulance in Vice City, which features a green-white paint scheme) and complete with it's letters on backwards. Throughout the series the siren sound has varied slightly, as has the design of the vehicle itself. If the player decides to go on a killing spree and many pedestrians are killed, an ambulance will arrive and two paramedics will get out and attempt to revive the wounded. Typically if paramedics are killed it creates more police attention than other civilians.
In all games between GTA III and GTA Vice City Stories, the player receives 20 points of health upon entering an Ambulance. In Grand Theft Auto IV, the player can even dial 911 to summon an Ambulance, from which the player can replenish their health for a price, or steal to regain some, but not all, of their health.
Ambulances in GTA 1 and GTA III through to GTA Vice City Stories are based on various generations of the Ford E-Series chassis, mainly the third and fourth generations, while the GTA London rendition is based on a European or British model, although given its angle, the vehicle's origins is unknown. Furthermore, the sound of the siren on each vehicle is distinct. Although the Ambulance in GTA IV sports a "Brute" badge on the front, it is clearly a modified version of the Declasse Burrito. The Ambulance that appears in the trailer for GTA V appears mostly identical to its GTA IV rendition.